ࡱ> VXU #bjbj 0P8|<&  %%%%%%%,[),r$&$&9&%%V$@$|cZF$ %O&0&R$x,,$$J%$&$&&, :  Xiang WangAddress:Department of Chemistry and Biochemistry University of Colorado at BoulderBoulder, CO 80309Phone: 303-492-6266Fax: 303-492-5894Email: xiang.wang@colorado.eduEducation:Postdoc Department of Chemistry and Chemical Biology, Harvard University 2008 Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA Advisor: Stuart L. SchreiberPh.D. Organic Chemistry, Department of Chemistry 2005Boston University, Boston, MAAdvisor: John A. Porco, Jr.B.S. Chemistry, University of Science and Technology of China 1999Hefei, ChinaEmployment:Assistant Professor of Chemistry and Biochemistry, University of Colorado Boulder 2008-presentAdministrative Responsibilities:Director, Center of High-Throughput Screening, CU Boulder 2010-presentOrganic Division Chair, Graduate Student Admission Committee, CU Boulder 2009-presentCo-chair, Organic Seminar Series, CU Boulder 2010-presentHonors & Awards:Sugata Ray Memorial Award, Boston University 2004CRCW Junior Faculty Development Award, University of Colorado 2009Butcher Award, Colorado Initiative in Molecular Biotechnology, University of Colorado 2010Golfers Against Cancer, University of Colorado Cancer Center 2012Professional Affiliation: Member American Chemical Society Member American Association for the Advancement of Science Member Colorado Clinical & Translational Sciences Institute Member University of Colorado Cancer CenterConferences, Invited Lectures, Posters (2008-present):05/2010 NIH Junior Faculty Workshop, Dallas, TX Specific Chemical Probes for Histone Demethylases12/2010 Molecular Oncology Retreat, University of Colorado Cancer Center, Boulder, CO Histone Demethylase Inhibitors09/2011 Chemistry Seminar, Hoffmann-La Roche, Nutley, NJ I. Lost in Hydroxylation and II. Bio-Inspired Synthesis of Indole Alkaloids10/2011 30th Annual High School-University Chemistry Teachers' Conference, Boulder, CO Organic Synthesis: from Learning to Creation11/2011 Butcher Symposium, Westminster, CO A Chemical Genetics Approach to Study Epigenetics Regulation in Mammalian Skin 05/2012 Chemical Biology Seminar, Shandong University, Jinan, China Lost in Hydroxylation07/2012 Gordon Research Conference on Bioorganic Chemistry Division, Andover, NH Specific Chemical Probes for Histone Demethylases 10/2012 Chemistry Seminar, University of Toledo, Toledo, OH Development ofBioprobes: An Organic Chemist's Approach03/2013 Chemical Epigenetics and Host Factors in Infectious Disease Symposium, Vienna, AustriaHistone Demethylases: A Chemist's Perspective06/2013 Gordon Research Conference on High-throughput Chemistry and Chemical Biology, NH Bio-inspired Synthesis Yields A Tricyclic Indoline That Selectively Resensitizes MRSA to (-Lactam Antibiotics Publications:18. Bio-inspired Synthesis Yields A Tricyclic Indoline That Selectively Resensitizes MRSA to (-Lactam Antibiotics, Podoll, J.; Liu, Y.; Chang, L.; Walls, S.; Wang, W.; Wang, X.* submitted. 17. Quantitative Analysis of Histone Demethylase Probes Using Fluorescence Polarization, Xu, W.; Podoll, J.; Dong, X.; Wang X.* J. Med. Chem. in press. Highlighted in Nature SciBX.16. A One-Pot Three-Component Reaction for the Preparation of Highly Functionalized Tryptamines, Yeo, S. J.; Liu, Y.; Wang, X.* Tetrahedron. 2012, 68, 813818.15. A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases, Luo, X.; Liu, Y.; Kubicek, S.; Myllyharju, J.; Tumber, A.; Ng, S.; Che, K.; Podoll, J.; Heightman, T. D.; Oppermann, U.; Schreiber, S. L.; Wang, X.* J. Am. Chem. Soc. 2011, 133, 94519456. Highlighted in Nature SciBX.14. Selective Gold(I)-Catalyzed Formation of Tetracyclic Indolines: A Single Transition State and Bifurcations Lead to Multiple Products, Noey, E.; Wang, X.; Houk, K. J. Org. Chem. 2011, 76, 34773483.13. AAK1 Identified as an Inhibitor of Neuregulin-1/ErbB4-Dependent Neurotrophic Factor Signaling Using Integrative Chemical Genomics and Proteomics, Kuai, L; Ong, S. E.; Madison, J. M.; Wang, X.; Duvall, J. R.; Lewis, T. A.; Luce, C. J.; Conner, S. D.; Pearlman, D. A.; Wood, J. L.; Schreiber, S. L.; Carr, S. A.; Scolnick, E. M.; Haggarty, S. J. Chem & Biol. 2011, 18, 891906.12. Gold(I)-Catalyzed Tandem Cyclization Approach to Tetracyclic Indolines, Liu, Y.; Xu, W.; Wang, X.* Org. Lett. 2010, 12, 14481451. 11. Chemical Genetics Identifies Small-Molecule Modulators of Neuritogenesis Involving Neuregulin-1/ErbB4 Signaling, Kuai, L.;Wang, X.; Madison, J. M.; Schreiber, S. L.; Scolnick, E. M.;Haggarty, S. J. ACS Chem. Neurosci. 2010, 1, 325342.10. Syntheses of Aminoalcohol-Derived Macrocycles Leading to a Small-Molecule Binder to and Inhibitor of Sonic Hedgehog, Peng, L.F.; Stanton, B. Z.; Maloof, N.; Wang, X.; Schreiber, S. L. Bioorg. Med. Chem. Lett. 2009, 19, 63196325.9. Identifying the Proteins to Which Small-Molecule Probes and Drugs Bind in Cells, Ong, S.-E.; Schenone, M.; Margolin, A.; Li, X.; Do, K.; Doud, M.; Mani, D.; Kuai, L.; Wang, X.; Wood, J.; Tolliday, N.; Koehler, A.; Marcaurelle, L.; Golub, T.; Gould, R.; Schreiber, S. L.; Carr, S. Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 46174622.8. A Small Molecule that Binds Hedgehog and Blocks its Signaling in Human Cells, Stanton, B.; Peng, L. F.; Maloof, N.; Nakai, K.; Wang, X.; Duffner, J. L.; Taveras, K. M.; Hyman, J. M.; Lee, S. W.; Koehler, A. N.; Chen, J. K.; Fox, J. L.; Mandinova, A.; Schreiber; S. L. Nature Chem. Biol. 2009, 5, 154156.7. Diversity Synthesis of Complex Pyridines Yields a Probe of a Neurotrophic Signaling Pathway, Gray, B. L.; Wang, X.; Schreiber, S. L. Org. Lett. 2008, 10, 26212624. 6. Small-Molecule Reagents for Cellular Pull-down Experiments, Wang, X.; Imber, B. S.; Schreiber, S. L. Bioconjug. Chem. 2008, 19, 585587. 5. Synthesis of the Tetracyclic Core of the Tetrapetalones via Transannular Oxidative [4+3] Cyclization, Wang, X.; Porco, J. A., Jr. Angew. Chem., Int. Ed. Eng. 2005, 44, 30673071; 2006, 45, 6607. 4. Total Synthesis of the Salicylate Enamide Macrolide Oximidine III: Application of Relay Ring-Closing Metathesis, Wang, X.; Bowman, E. J.; Bowman, B. J.; Porco, J. A., Jr. Angew. Chem., Int. Ed. Eng. 2004, 43, 36013605. 3. Total Synthesis of the Salicylate Enamide Macrolide Oximidine II, Wang, X.; Porco, J. A., Jr. J. Am. Chem. Soc. 2003, 125, 60406041. 2. Modification of C-Terminal Peptides to Form Peptide Enamides: Synthesis of Chondriamides A and C, Wang, X.; Porco, J. A., Jr. J. Org. Chem. 2001, 66, 82158221. 1. Parallel Synthesis and Purification Using Anthracene-Tagged Substrates, Wang, X.; Parlow, J. J.; Porco, J. A., Jr. Org. Lett. 2000, 2, 35093512. Patent Filed:1. Histone Demethylase Inhibitors and Methods for Using the Same, Xu, W.; Wang, X. US 2013/0137720 A1.2. Indoline Alkaloid Compounds, Wang, X. CU3309B-PPA1.   l m  R V W c d p # 3 9 D I P Q Y 9 = ϲϲϼϲϲϢ hDZj5 hHdhDZjhWhThT56hT h hXdhXdhDZjhHdhDZj5h hDZj5 h2FhDZj h hDZjh2FhDZj5h hDZj5CJ = Cew m W d p 0^gdDZj0^`gdDZj0x^gdDZjxgdDZj ^gdDZj^gdDZjxxgdDZj$a$gdDZjp Q > 9S}#& 0 P@x1$7$8$H$gdDZj#& 0 P@1$7$8$H$^gdDZj#& 0` P@x1$7$8$H$gdDZj x^gdDZjgdW^gdDZj )489SBIPQRSxs{~$%Uμ||n_RnhKOhKOB*aJphhKOhKOB*\aJphhKO0J6B*aJphhe;0J6B*aJphh;0J6B*aJphh{5B*aJphh{B*aJphh{0J6B*aJph hDZj5hBShBS5 hBS5 h{5 h h!hDZj h hDZjh hDZj5h!h!5h! h!h! SuSE%U{$`^``a$gdKO$`x^``a$gdKO$`^``a$gd;$`x^``a$gd{$#^#`a$gd{$x^`a$gd{xgdDZj$0TT^T`a$gdDZj0RU,.68AGI_himqr򬟕~qqqqqaq jbhq_hXdB*aJphhq_hXdB*aJphhXdhXdB*aJphhXdB*aJphhJF'B*aJphhJF'hJF'B*aJphhJF'0J6B*aJphhXd0J6B*aJphhKO0J6B*aJphh{0J6B*aJphh;0J6B*aJphhe;0J6B*aJph$0.Wzz$hx^h`a$gdTxgdDZj$a$gdXd $^a$gdXd$`x^``a$gdXd$`x^``a$gdJF'$`^``a$gd;$`^``a$gdKO$`x^``a$gd; !*67AJKTɼteYhXd6B*aJphhThT5B*aJphhThTB*aJphh!B*aJphhThXdB*aJphhTB*aJph jbhq_hq_B*aJphhXdB*aJphhq_hq_B*aJphhXd0J6B*aJphhT0J6B*aJph hDZj5h hDZj5h{hXdB*aJphTUV\Oϵ痋ugYgYLh[Jh[JB*aJphh[J0J6B*aJphhDZj0J6B*aJphhXd0JB*aJphhXdB*aJphhXd6B*aJphhXdhXd6B*aJphhThT5B*aJphhTh!B*aJphhThTB*aJphh!B*aJphhT0J6B*aJphhTB*aJphhThT6B*aJphOptuwyz|謚zk_N h4h[J0J6B*aJphh[J0JB*aJphh4h[J0JB*aJph h9h[J0J6B*aJphh[J0J56B*aJph#h9h[J0J56B*aJph#h[Jh[J0J56B*aJphh[Jh[J6B*aJphh[J5B*aJphh[Jh[J5B*aJphh[Jh[JB*aJphh[JB*aJph#+ο򱠱}n\}nQnEhXd0JB*aJphh hDZj^J_H #h9hDZj0J56B*aJphh4hDZj0JB*aJph h9hDZj0J6B*aJph#h4hDZj0J56B*aJph h4hDZj0J6B*aJphhDZj0J6B*aJphh4h[J0JB*aJphh[J^J_H h h[J^J_H  h4h[J0J6B*aJphh[J0J6B*aJphMHn,$& ` P@hx1$7$8$H$^h`a$gd$hx1$7$8$H$^h`a$gdDZj)$& 0` P@hx1$H$^h`a$gdDZj$hx^h`a$gd?$hx^h`a$gdDZj -9:>@BGHMⶤ}u}j^jRjFjRjjh9hDZj5^J_H h9hDZj6^J_H h?hDZj5^J_H h9hDZj^J_H h?^J_H hZGhDZj^J_H h hDZj^J_H  hjhDZj0J6B*aJph#hjhDZj0J56B*aJphhyBhDZj0JB*aJph#hyBhDZj0J56B*aJphhyBhDZj^JaJ$hDZj0J6B*aJphh9hDZj0JB*aJphMNOPZbϾﯝ|m\mMm>hZGhDZj0JB*aJphhZGhDZj0JB*aJph333 h0phDZj0J5B*aJph333hZGhDZj0JB*aJph333hZGhDZjB*phhZGhDZj^J_H h h?^J_H #hZGh?0J56B*aJphhZGh?0JB*aJph h9h?0J6B*aJph#h0ph?0J56B*aJphh?0J6B*aJph hZGh?0J6B*aJphqxhp︬øzoaQah0phDZj5\^J_H aJhZGhDZj\^J_H aJhZGhDZj^J_H hZGhDZj^J_H aJ$hZGhDZj^J_H aJhZGhDZj5^J_H hZGhDZj6^J_H h0phDZj5^J_H hZGhDZj^J_H h hDZj^J_H hZGhDZj0JB*aJph#hZGhDZj0J56B*aJph hZGhDZj0J6B*aJph  +,>?IJVW\]acd#6𼱦ykh hDZj6^J_H aJh0phDZj5^J_H aJh hDZj^J_H aJh^J_H aJh^J_H hh^J_H hZGhDZj^J_H h hDZj^J_H h hDZj^J_H hZGhDZj\^J_H aJhZGhDZj5\^J_H aJhZGhDZj6\^J_H aJ$6:;=BCGHJKL568@brtxzɾɱuguuu[h hDZj5^J_H h hDZj5]^J_H h hDZj]^J_H h hDZj6]^J_H h0phDZj5^J_H hZGhDZj^J_H h hDZj^J_H hhDZj^J_H aJh hDZj^J_H h!hDZj^J_H aJh hDZj6^J_H aJhzXEhDZj^J_H aJhzXEhDZj5^J_H aJ#HT 9!!r"#####rrr,$& ` P@hx1$7$8$H$^h`a$gdoxgdo,$& ` P@hx1$7$8$H$^h`a$gdJ,$& ` P@hx1$7$8$H$^h`a$gdDZj z| . 2 4 6 B G I K R T V W X !#!'!)!+!8!9!;!6666666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~_HmH nH sH tH @`@ NormalCJ_HaJmH sH tH DA`D Default Paragraph FontRiR  Table Normal4 l4a (k (No List 0U`0 2F Hyperlink>*B*@V`@ 2FFollowedHyperlink>*B* 44 \Header!4 "4 \Footer!8O18 ZGapple-style-spanBOAB ZGapple-converted-space.a`Q. ZG HTML Cite6,X`a, BEmphasis6H@rH !0 Balloon TextCJOJQJ^JaJNoN !0Balloon Text CharCJOJQJ^JaJPK!pO[Content_Types].xmlj0Eжr(΢]yl#!MB;.n̨̽\A1&ҫ QWKvUbOX#&1`RT9<l#$>r `С-;c=1g~'}xPiB$IO1Êk9IcLHY<;*v7'aE\h>=^,*8q;^*4?Wq{nԉogAߤ>8f2*<")QHxK|]Zz)ӁMSm@\&>!7;wP3[EBU`1OC5VDXa?p S4[NS28;Y[꫙,T1|n;+/ʕj\\,E:! t4.T̡ e1}; [z^pl@ok0eg@GGHPXNT,مde|*YdT\Y䀰+(T7$ow2缂#G֛ʥ?q NK-/M,WgxFV/FQⷶO&ecx\QLW@H!+{[|{!KAi`cm2iU|Y+ ި [[vxrNE3pmR=Y04,!&0+WC܃@oOS2'Sٮ05$ɤ]pm3Ft GɄ-!y"ӉV .`עv,O.%вKasSƭvMz`3{9+e@eՔLy7W_XtlPK!ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э56?$Q,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-!pO[Content_Types].xmlPK-!֧6 -_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!!Z!theme/theme/theme1.xmlPK-!ѐ'( theme/theme/_rels/themeManager.xml.relsPK]# P  TOM6z!h## !"$%&p SH###'8@0( ,|p/|0@ B S  ? _Hlt80181207@  cn&)8?EOU[il~gkps %-1%PTIMek&,4JN^b}qu~ BGbk`bH J #)dkRWMTFM5<t,.R!~-4::::::::::::::::::::::::1ZD·3FaV^^`o(. TT^T`hH. $ L$ ^$ `LhH.   ^ `hH. ^`hH. L^`LhH. dd^d`hH. 44^4`hH. L^`LhH.h^`OJQJo(hHh^`OJQJo(hHoh  ^ `OJ QJ o(hHh\\^\`OJQJo(hHh,,^,`OJQJo(hHoh^`OJ QJ o(hHh^`OJQJo(hHh^`OJQJo(hHohll^l`OJ QJ o(hHh^`OJQJo(hHhpp^p`OJQJo(hHoh@ @ ^@ `OJ QJ o(hHh^`OJQJo(hHh^`OJQJo(hHoh^`OJ QJ o(hHh^`OJQJo(hHhPP^P`OJQJo(hHoh  ^ `OJ QJ o(hHa3F1ZD5$                          c%"21?u`@eFAN~Bs BSXdUT# JF';/BEJKOWa:Zq_?liAoiDZj#}lLCq?ooU{-[JJe;Rn~!@Nqzx@Unknown G*Ax Times New Roman5Symbol3 *Cx ArialkTimesNewRomanPSMTTimes New Roman;[xPHelvetica7 [ @VerdanaC ArialMTArialC  PLucida Grande? *Cx Courier New;WingdingsA$BCambria Math Ahj:j:q}&$2$2a(24 K#qP?d2! xx , Xiang Wangresume Xiang Wang Xiang Wang    Oh+'0D  , P \ ht' Xiang Wangresume Xiang Wang Normal.dotm Xiang Wang2Microsoft Macintosh Word@G@n[@Tc@Tc$GPICTb HHb bHH{ْbbwZkZ{^c{#=NsF19Ns=F1F1Z5F1B{!{wswF1wssNswVg9RNsco{g9o{o{kZEkZg9o{o{skZo{o{kZ{kZkZsg9o{{so{g9kZcswg9o{o{so{o{{E o{cc^o{g9cg9g9sg9wwg9ckZo{g9 o{cg9o{g9ckZkZg9kZs9o{o{swwso{w{o{wo{swkZwg9o{wo{kZs{6o{kZco{g9csg9wsccg9g9^g9g9o{kZcc^%swwwwsswso{so{#cVZVRNssg9kZ^ZcZֺ%w{ w{w{w{w{޼)cV^Zg9{kZVkZkZVcsZkZRg9${w{{{w{w{{޼%cg9o{{g9Zg9kZVckZg9ZV^%wo{s{wswws{wsww;g9o{so{o{{o{wss{so{sso{swo{sskZw{o{kZ=o{kZc^o{{cg9g9Vo{kZ^^c^g9g9cg9g9cg9kZg9^{Vg9g9o{o{ckZkZs^ZV^Z^VVo{}o{wwsss{w{{so{s{{w{{swo{{ wo{ss{ss{ssw{{{s{g9g9cg9g9c^Z{kZ^V^Z-^VkZco{kZZ^ZZVg9g9^ZZkZo{Z^ZZ^g9cZ^^ZZsg9ZVg9^ZkZkZcZcVcZg9^JRNsRo{s{{s{{{ww{{w{o{o{w{{wss{{w{{{{w{3g9g9Z^ZVZkZZZ^VVco{^cV^RZscRZZVg9ZRVZZo{^kZcVZg9NsccRZg9ZV^{g9o{V^^{V^^H{ {{ss{s{{{{{o{{{3s^^g9kZg9o{o{Zg9kZ^g9s^cckZZckZ+{swswsw{so{o{sww{swecZo{c kZco{kZo{o{{g9co{kZo{sZo{kZo{g9kZo{kZo{sg9kZg9o{kZo{kZkZs{^JRRV_so{ {skZcckZkZ{o{kZo{kZ o{kZwg9o{cg9o{kZg9o{sskZo{kZg9g9kZg9ccs7kZg9so{sso{sso{kZsg9kZso{o{wo{cs{9o{ckZg9g9o{skZg9skZg9g9cwo{g9cg9g9kZwcso{/{wo{{{w{s{sg9{{s1sZc^cZkZo{^ZZsg9{c^ZckZkZg9Kw{s{sw{ww{ww{{wwso{su^cZ!g9g9VZVRRcwg9^Vg9ZVVZo{ZsZV^V^cZVRo{g9ZVRZwZg9cZVVkZZJRJRR{wwwo{ g9Z^g9sg9o{^^g9ws{wsJRc^^Vc^^g9g9g9^Zg9co{g9kZ o{kZo{kZkZg9g9o{^o{ckZo{sckZg9o{kZkZg9g9o{wkZo{kZRkZo{g9o{kZkZg9g9o{{kZ!o{o{kZg9o{wg9kZso{g9kZo{co{g9co{g9ckZwg9RF1F1scg9g9kZckZwkZkZo{kZckZwsso{o{kZkZsso{sskZo{kZ{g9kZskZo{kZ skZg9kZkZwso{kZwo{o{kZg9wkZ{so{kZo{kZg9o{skZo{kZg9kZ{o{g9^g9kZo{kZg9s1w{www{{{wkZwskZsw;NsNsF1B=BNsF1F1RF1RkZF1R9F1F1JRJRB=BNsJR^ wJw{{{{w{{s{www{{{w{.kZV^cc^kZg9o{^Zg9kZckZg9ZcZwV^g9VcZZ^kZZkZZ^Z^co{g9{^o{^^cZVkZ cF1NsBcNs^VZRcq w{{w{{w{ww{wg9w{w{{g9wo{w{w{ww{wskZ{w{{w{w{o{{w{*g9^g9kZg9g9wVg9g9o{g9g9o{kZ^o{cg9ckZ^kZco{o{^kZ^g9c{^^g9g9kZg9kZg9kZo{g9cckZo{{g9g9sRkZg9c^g9 cNsBBkZ^g9cg9^kZwo{ckZo{kZ{o{wo{so{swso{wso{kZkZg9o{o{{o{o{kZkZo{wskZo{o{so{wso{ swss{o{o{kZo{kZs o{kZkZwg9kZsskZkZw_kZscg9o{wckZg9skZg9kZsckZ s{kZkZwRo{kZg9ckZ cRZNso{ckZg9kZckZdso{kZg9swo{o{Zg9kZo{wkZo{kZo{cwskZo{kZo{wo{s{g9kZg9o{ kZg9kZg9^g9kZo{g9g9s%Vg9kZo{ sg9g9kZo{o{^sw'^ZVZZcg9ZwcZZkZVcwT s{wg9{{o{o{{sw{{s {w{sw{{{{wg9o{] g9ZVZ^o{V^g9o{ZcZ^^sc^^ZckZVc^^ZkZg9Zg9c^^Z{^JRNsZ]{so{ss{{{{{{{s{{{ww{{{swswyg9cRs^g9g9Z)g9kZVZRg9o{ZccV^VZZ^Vs^VZZckZsZZ^^ZZs^kZg9kZVZVRZ{Z=BR5{{w{s{{{{{{{C^Zcc^g9{^co{g9^wg9g9ccg9^g9g9c^g9cckZs^sZcZg9o{^kZo{NscckZo{Z^g9cckZg9cckZcg9^kZs^g9sg9^cg9Zo{ZBRNsxwsso{so{{wso{{so{sws {o{{wsso{so{o{{o{sg9o{w s{o{wss{swso{o{wkZskg9g9c^g9kZsg9kZg9o{co{kZkZg9g9o{g9g9co{wcg9skZcg9kZ^o{g9o{g9kZo{o{g9kZg9^JR^^lwo{so{o{s{kZco{{so{o{kZo{wsso{wkZso{o{wo{{wo{o{skZkZso{kZswsso{g9o{o{kZ-F1kZkZVg9o{^g9kZ^scNsNsckZkZ{޻/kZo{cZcg9Z^Zcw^cZ^Z^^g9{޻? o{o{{skZ{wo{w{w{so{wswwo{sw{ws{A sZc^^ZkZc^cg9^kZs^^c^c^wZ^g9Zg9?www{{ {ws{wwwkkZR^R,cZVZVZ^Ro{Z^VZcRVVg9^VsRRs^Rg9RR^ZVRRo{Zo{VZZVZg9!{{{{{eg9VkZ^Z^kZso{c^^g9Zg9 cco{g9kZRg9c^^c^cg9kZcg9g9cg9g9kZcZg9c^o{]{wss{w ssw{wswws{o{wswswwswwswsw{wswwQcVkZcZckZ{ccg9o{g9g9co{o{cg9o{^g9 ^scg9cg9g9kZo{kZcco{9{swsswswso{o{{so{so{w[Zg9cZc#g9g9Nsg9^cc^^sg9cg9^cVZc^cg9o{^NsJRJRo{g9ccg9^ckZ[kZkZckZg9g9kZ^kZkZs^o{g9kZckZkZg9kZkZcg9kZkZo{o{cg9g9o{o{g9ccg9kZg9^kZkZ ՜.+,D՜.+,<x  '$UNIVERSITY OF COLORADO AT BOULDER2  Xiang Wang TitleP :B_PID_LINKBASE'A  !"#$%&'(*+,-./0123456789:;<=>?ABCDEFGHIJKLNOPQRSTWRoot Entry F.|cY1Table),WordDocument0PSummaryInformation(@tDocumentSummaryInformation8MCompObj` F Microsoft Word 97-2004 DocumentNB6WWord.Document.8